Greyling, who made his debut for the men in blue in 2008 against the Lions, will again line-up in a front row that will also consist of Callie Visagie (hooker) and Marcel van der Merwe (tighthead) as Vodacom Bulls coach Frans Ludeke retained his starting pack for the clash.
Ludeke made one change to the backline that started against the Toyota Cheetahs last week though, with JJ Engelbrecht back in the number 13 jersey for the clash against the Cape side.
Engelbrecht swops places with William Small-Smith, who moves to the bench for the north/south derby.
Victor Matfield will again lead the side as Flip van der Merwe serves his last week of suspension.
According to the veteran lock, who will play in his 135th Vodacom Super Rugby match, the Vodacom Bulls must maintain the momentum they picked up in the second half of the match against the Cheetahs.
The team (with Super Rugby caps) is: Jurgen Visser (21), Akona Ndungane (104), JJ Engelbrecht (44), Jan Serfontein (23), Bjorn Basson (66), Handré Pollard (9), Francois Hougaard (67), Grant Hattingh (30), Jacques du Plessis (12), Jono Ross (14), Victor Matfield (134, c), Paul Willemse (15), Marcel van der Merwe (14), Callie Visagie (33), Dean Greyling (49). Replacements: Bongi Mbonambi (11), Werner Kruger (103), Morné Mellett (19), Jacques Engelbrecht (22), Wimpie van der Walt (19), Rudy Paige (6), Jacques-Louis Potgieter (51), William Small-Smith (3).